Drug interactions
Procarbazine + Trimipramine
Severity: Contraindicated
Procarbazine and Trimipramine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting activity, so combining it with a tricyclic may lead to serotonin syndrome or hypertensive reactions. The risk persists for some time after stopping an MAOI.
What this interaction means in plain words
Procarbazine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
MAO inhibition by procarbazine plus monoamine reuptake inhibition by trimipramine leads to excess serotonergic and adrenergic stimulation.
What to do
Avoid the combination; allow about 14 days between stopping procarbazine and starting trimipramine, and vice versa as labeled. Use an alternative antidepressant in patients on procarbazine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Trimipramine?
MediHelp rates the interaction as contraindicated. Procarbazine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting activity, so combining it with a tricyclic may lead to serotonin syndrome or hypertensive reactions. The risk persists for some time after stopping an MAOI.
How serious is the interaction between Procarbazine and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; allow about 14 days between stopping procarbazine and starting trimipramine, and vice versa as labeled. Use an alternative antidepressant in patients on procarbazine.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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