Drug interactions
Prochlorperazine + Pseudoephedrine
Severity: Moderate
Prochlorperazine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pseudoephedrine can increase heart rate and arrhythmia risk, while prochlorperazine can prolong the QT interval and cause alpha-blockade. The combination may modestly raise the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Prochlorperazine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Pseudoephedrine belongs to Respiratory.
Why it happens
Combined pharmacodynamic effects of sympathomimetic cardiac stimulation and phenothiazine QT prolongation.
What to do
Avoid in patients with QT prolongation, structural heart disease or electrolyte disturbance; otherwise monitor heart rate, rhythm and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Prochlorperazine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pseudoephedrine can increase heart rate and arrhythmia risk, while prochlorperazine can prolong the QT interval and cause alpha-blockade. The combination may modestly raise the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Prochlorperazine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with QT prolongation, structural heart disease or electrolyte disturbance; otherwise monitor heart rate, rhythm and blood pressure.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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