Drug interactions
Prochlorperazine + Pyrimethamine
Severity: Minor
Prochlorperazine and Pyrimethamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrimethamine may modestly raise prochlorperazine levels, but this is poorly documented. Both drugs can cause bone marrow suppression, which is a theoretical additive concern.
What this interaction means in plain words
Prochlorperazine and Pyrimethamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prochlorperazine belongs to Central Nervous System; Pyrimethamine belongs to Anti Parasitic.
Why it happens
Possible reduced prochlorperazine metabolism; the mechanism is not well established.
What to do
Monitor for sedation and extrapyramidal effects. Check blood counts if therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Pyrimethamine
- Deferiprone + Pyrimethamine Major
- Eliglustat + Pyrimethamine Major
- Acalabrutinib + Pyrimethamine Moderate
- Brexpiprazole + Pyrimethamine Moderate
- Dapsone + Pyrimethamine Moderate
- Folic acid + Pyrimethamine Moderate
Frequently asked questions
Can I take Prochlorperazine with Pyrimethamine?
MediHelp rates the interaction as minor. Prochlorperazine and Pyrimethamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pyrimethamine may modestly raise prochlorperazine levels, but this is poorly documented. Both drugs can cause bone marrow suppression, which is a theoretical additive concern.
How serious is the interaction between Prochlorperazine and Pyrimethamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and extrapyramidal effects. Check blood counts if therapy is prolonged.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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