Drug interactions
Prochlorperazine + Rocuronium
Severity: Minor
Prochlorperazine and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no well-established clinically significant interaction between prochlorperazine and rocuronium. Phenothiazines might slightly enhance neuromuscular blockade, but evidence is limited.
What this interaction means in plain words
Prochlorperazine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prochlorperazine belongs to Central Nervous System; Rocuronium belongs to Musculoskeletal.
Why it happens
Possible weak additive effect at the neuromuscular junction; the mechanism is not established.
What to do
Monitor neuromuscular blockade with a nerve stimulator and titrate rocuronium to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Rocuronium
Frequently asked questions
Can I take Prochlorperazine with Rocuronium?
MediHelp rates the interaction as minor. Prochlorperazine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no well-established clinically significant interaction between prochlorperazine and rocuronium. Phenothiazines might slightly enhance neuromuscular blockade, but evidence is limited.
How serious is the interaction between Prochlorperazine and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with a nerve stimulator and titrate rocuronium to effect.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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