Drug interactions
Prochlorperazine + Safinamide
Severity: Major
Prochlorperazine and Safinamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine blocks dopamine receptors and can counteract the dopaminergic benefit of safinamide in Parkinson disease. Motor symptoms may worsen and parkinsonism may be aggravated.
What this interaction means in plain words
Prochlorperazine and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Prochlorperazine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Central D2 receptor antagonism by prochlorperazine opposes the dopaminergic effect of safinamide, which acts through MAO-B inhibition and increased dopamine.
What to do
Avoid prochlorperazine in patients with Parkinson disease. Use an antiemetic without central dopamine blockade, such as domperidone where available or ondansetron, and monitor motor function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Prochlorperazine with Safinamide?
MediHelp rates the interaction as major. Prochlorperazine and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prochlorperazine blocks dopamine receptors and can counteract the dopaminergic benefit of safinamide in Parkinson disease. Motor symptoms may worsen and parkinsonism may be aggravated.
How serious is the interaction between Prochlorperazine and Safinamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prochlorperazine in patients with Parkinson disease. Use an antiemetic without central dopamine blockade, such as domperidone where available or ondansetron, and monitor motor function.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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