Drug interactions
Prochlorperazine + Salbutamol
Severity: Minor
Prochlorperazine and Salbutamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine can prolong the QT interval, and salbutamol may add arrhythmic risk via tachycardia and hypokalemia. Risk is mainly relevant in patients with underlying cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Prochlorperazine and Salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prochlorperazine belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Additive proarrhythmic effects: phenothiazine QT prolongation plus beta-agonist-induced hypokalemia.
What to do
Monitor potassium and ECG in patients with QT risk factors. Use the lowest effective doses of both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salbutamol
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Salbutamol?
MediHelp rates the interaction as minor. Prochlorperazine and Salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prochlorperazine can prolong the QT interval, and salbutamol may add arrhythmic risk via tachycardia and hypokalemia. Risk is mainly relevant in patients with underlying cardiac disease or electrolyte abnormalities.
How serious is the interaction between Prochlorperazine and Salbutamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and ECG in patients with QT risk factors. Use the lowest effective doses of both drugs.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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