Drug interactions
Prochlorperazine + Scopolamine
Severity: Moderate
Prochlorperazine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combined use can cause additive dry mouth, blurred vision, constipation, urinary retention, sedation and confusion. Older patients are especially susceptible.
What this interaction means in plain words
Prochlorperazine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive antimuscarinic and sedative effects at central and peripheral receptors.
What to do
Monitor for anticholinergic toxicity and cognitive effects, particularly in older adults. Avoid the combination in patients with glaucoma or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Scopolamine
Frequently asked questions
Can I take Prochlorperazine with Scopolamine?
MediHelp rates the interaction as moderate. Prochlorperazine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use can cause additive dry mouth, blurred vision, constipation, urinary retention, sedation and confusion. Older patients are especially susceptible.
How serious is the interaction between Prochlorperazine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and cognitive effects, particularly in older adults. Avoid the combination in patients with glaucoma or urinary retention.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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