Drug interactions
Prochlorperazine + Tolterodine
Severity: Moderate
Prochlorperazine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combined use can increase constipation, dry mouth, urinary retention, blurred vision and cognitive impairment. Older patients are at greatest risk. Tolterodine may also contribute to QT prolongation.
What this interaction means in plain words
Prochlorperazine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive anticholinergic effects.
What to do
Monitor for anticholinergic adverse effects and reassess the need for both drugs, particularly in elderly patients. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Tolterodine
Frequently asked questions
Can I take Prochlorperazine with Tolterodine?
MediHelp rates the interaction as moderate. Prochlorperazine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use can increase constipation, dry mouth, urinary retention, blurred vision and cognitive impairment. Older patients are at greatest risk. Tolterodine may also contribute to QT prolongation.
How serious is the interaction between Prochlorperazine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reassess the need for both drugs, particularly in elderly patients. Use the lowest effective doses.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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