Drug interactions
Prochlorperazine + Tretinoin
Severity: Minor
Prochlorperazine and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can cause photosensitivity, and tretinoin also increases photosensitivity of the skin. The combination might intensify sunburn-like reactions. For topical tretinoin the effect is mainly local, and the interaction is largely theoretical.
What this interaction means in plain words
Prochlorperazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prochlorperazine belongs to Central Nervous System; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects of the two drugs.
What to do
Advise patients to use sun protection and to avoid excess UV exposure. Reduce tretinoin use if skin irritation develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Prochlorperazine with Tretinoin?
MediHelp rates the interaction as minor. Prochlorperazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines can cause photosensitivity, and tretinoin also increases photosensitivity of the skin. The combination might intensify sunburn-like reactions. For topical tretinoin the effect is mainly local, and the interaction is largely theoretical.
How serious is the interaction between Prochlorperazine and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to use sun protection and to avoid excess UV exposure. Reduce tretinoin use if skin irritation develops.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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