Drug interactions
Progesterone + Rifabutin
Severity: Moderate
Progesterone and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin may reduce progesterone concentrations and diminish hormonal effects. Contraceptive failure or breakthrough bleeding may occur.
What this interaction means in plain words
Progesterone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Progesterone belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4, increasing progesterone metabolism.
What to do
Advise non-hormonal contraception during and after rifabutin use. Monitor for bleeding irregularities or loss of effect if progesterone is used therapeutically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Progesterone with Rifabutin?
MediHelp rates the interaction as moderate. Progesterone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin may reduce progesterone concentrations and diminish hormonal effects. Contraceptive failure or breakthrough bleeding may occur.
How serious is the interaction between Progesterone and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise non-hormonal contraception during and after rifabutin use. Monitor for bleeding irregularities or loss of effect if progesterone is used therapeutically.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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