Drug interactions
Propafenone + Triclabendazole
Severity: Moderate
Propafenone and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval, and propafenone has proarrhythmic potential. Combined use may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Propafenone and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propafenone belongs to Cardiovascular; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Obtain baseline ECG and correct hypokalemia and hypomagnesemia. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Propafenone with Triclabendazole?
MediHelp rates the interaction as moderate. Propafenone and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole can prolong the QT interval, and propafenone has proarrhythmic potential. Combined use may increase the risk of ventricular arrhythmia.
How serious is the interaction between Propafenone and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct hypokalemia and hypomagnesemia. Monitor for palpitations or syncope.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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