Drug interactions
Propofol + Rasagiline
Severity: Moderate
Propofol and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may alter hemodynamic responses to anesthetic agents. Evidence for rasagiline with propofol is limited.
What this interaction means in plain words
Propofol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction through altered catecholamine handling; mechanism not well established.
What to do
Inform the anesthesiologist and monitor blood pressure and heart rate, titrating propofol carefully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Rasagiline?
MediHelp rates the interaction as moderate. Propofol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may alter hemodynamic responses to anesthetic agents. Evidence for rasagiline with propofol is limited.
How serious is the interaction between Propofol and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesiologist and monitor blood pressure and heart rate, titrating propofol carefully.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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