Drug interactions
Propofol + Selegiline
Severity: Moderate
Propofol and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may alter hemodynamic responses to anesthetics, and unpredictable blood pressure changes have been described. Evidence for selegiline with propofol is limited.
What this interaction means in plain words
Propofol and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction; MAO inhibition alters catecholamine handling, though the mechanism is not firmly established.
What to do
Tell the anesthesia team about selegiline and monitor blood pressure and heart rate during induction and maintenance. Titrate propofol carefully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Selegiline?
MediHelp rates the interaction as moderate. Propofol and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may alter hemodynamic responses to anesthetics, and unpredictable blood pressure changes have been described. Evidence for selegiline with propofol is limited.
How serious is the interaction between Propofol and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about selegiline and monitor blood pressure and heart rate during induction and maintenance. Titrate propofol carefully.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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