Drug interactions
Propofol + Timolol
Severity: Moderate
Propofol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and a beta-blocker can limit the compensatory heart rate response, increasing hypotension and bradycardia during anesthesia or sedation.
What this interaction means in plain words
Propofol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Additive cardiovascular depression from propofol vasodilation and beta-blockade of compensatory sympathetic responses.
What to do
Titrate propofol slowly with continuous blood pressure and ECG monitoring, and have vasopressors and anticholinergics available. Continue beta-blockers perioperatively as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Timolol?
MediHelp rates the interaction as moderate. Propofol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and a beta-blocker can limit the compensatory heart rate response, increasing hypotension and bradycardia during anesthesia or sedation.
How serious is the interaction between Propofol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol slowly with continuous blood pressure and ECG monitoring, and have vasopressors and anticholinergics available. Continue beta-blockers perioperatively as indicated.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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