Drug interactions
Propofol + Zuranolone
Severity: Moderate
Propofol and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired psychomotor function. With propofol, sedation and respiratory depression may be greater than expected.
What this interaction means in plain words
Propofol and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive positive modulation of GABA-A receptors causing CNS depression.
What to do
Anesthesia teams should reduce and titrate propofol dosing and monitor ventilation. Advise patients not to drive after sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Propofol with Zuranolone?
MediHelp rates the interaction as moderate. Propofol and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired psychomotor function. With propofol, sedation and respiratory depression may be greater than expected.
How serious is the interaction between Propofol and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Anesthesia teams should reduce and titrate propofol dosing and monitor ventilation. Advise patients not to drive after sedation.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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