Drug interactions
Propranolol + Teriflunomide
Severity: Minor
Propranolol and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak CYP1A2 inducer and may slightly lower exposure to CYP1A2 substrates, and propranolol is partly metabolized by this enzyme. The clinical effect is expected to be small.
What this interaction means in plain words
Propranolol and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propranolol belongs to Cardiovascular; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak induction of CYP1A2 by teriflunomide increases propranolol clearance.
What to do
No routine dose change is needed. Monitor heart rate and blood pressure after teriflunomide is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Propranolol with Teriflunomide?
MediHelp rates the interaction as minor. Propranolol and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak CYP1A2 inducer and may slightly lower exposure to CYP1A2 substrates, and propranolol is partly metabolized by this enzyme. The clinical effect is expected to be small.
How serious is the interaction between Propranolol and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor heart rate and blood pressure after teriflunomide is started.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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