Drug interactions
Propranolol + Ticlopidine
Severity: Minor
Propranolol and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2D6 and other hepatic enzymes and may raise propranolol concentrations. This could modestly increase beta-blocker effects such as bradycardia and hypotension.
What this interaction means in plain words
Propranolol and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propranolol belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP-mediated hepatic metabolism of propranolol.
What to do
Monitor heart rate and blood pressure after ticlopidine is started or stopped and reduce the propranolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Propranolol with Ticlopidine?
MediHelp rates the interaction as minor. Propranolol and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticlopidine inhibits CYP2D6 and other hepatic enzymes and may raise propranolol concentrations. This could modestly increase beta-blocker effects such as bradycardia and hypotension.
How serious is the interaction between Propranolol and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after ticlopidine is started or stopped and reduce the propranolol dose if bradycardia or hypotension occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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