Drug interactions
Protriptyline + Rolapitant
Severity: Moderate
Protriptyline and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits CYP2D6 for a prolonged period, which can raise protriptyline concentrations. This may increase anticholinergic effects, sedation, tachycardia and arrhythmia risk.
What this interaction means in plain words
Protriptyline and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rolapitant inhibits CYP2D6-mediated metabolism of protriptyline.
What to do
Monitor for anticholinergic and cardiac effects, and consider an ECG in at-risk patients. Reduce the protriptyline dose if toxicity appears, as inhibition lasts at least 28 days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Protriptyline with Rolapitant?
MediHelp rates the interaction as moderate. Protriptyline and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits CYP2D6 for a prolonged period, which can raise protriptyline concentrations. This may increase anticholinergic effects, sedation, tachycardia and arrhythmia risk.
How serious is the interaction between Protriptyline and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic and cardiac effects, and consider an ECG in at-risk patients. Reduce the protriptyline dose if toxicity appears, as inhibition lasts at least 28 days.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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