Drug interactions
Quetiapine + Rucaparib
Severity: Minor
Quetiapine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak to moderate CYP3A inhibitor and may modestly raise quetiapine exposure. The effect would be greater sedation or hypotension.
What this interaction means in plain words
Quetiapine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Quetiapine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by rucaparib reduces quetiapine metabolism.
What to do
Monitor for increased sedation and orthostatic hypotension and adjust the quetiapine dose if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Quetiapine with Rucaparib?
MediHelp rates the interaction as minor. Quetiapine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak to moderate CYP3A inhibitor and may modestly raise quetiapine exposure. The effect would be greater sedation or hypotension.
How serious is the interaction between Quetiapine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and orthostatic hypotension and adjust the quetiapine dose if symptoms emerge.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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