Drug interactions
Quetiapine + Stiripentol
Severity: Moderate
Quetiapine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is sedating and affects CYP3A4, so it may change quetiapine exposure in either direction while also adding to its sedative effects. The net result is unpredictable and can include oversedation or reduced antipsychotic effect.
What this interaction means in plain words
Quetiapine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol together with additive CNS depression.
What to do
Monitor for sedation and for loss of quetiapine effect when stiripentol is started, changed or stopped. Adjust the quetiapine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Quetiapine with Stiripentol?
MediHelp rates the interaction as moderate. Quetiapine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is sedating and affects CYP3A4, so it may change quetiapine exposure in either direction while also adding to its sedative effects. The net result is unpredictable and can include oversedation or reduced antipsychotic effect.
How serious is the interaction between Quetiapine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for loss of quetiapine effect when stiripentol is started, changed or stopped. Adjust the quetiapine dose according to response.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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