Drug interactions
Quetiapine + Tiotropium-olodaterol
Severity: Moderate
Quetiapine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine has anticholinergic activity through its metabolite and can add to tiotropium antimuscarinic effects. It can also prolong the QT interval, which olodaterol-related hypokalemia and sympathetic stimulation may worsen.
What this interaction means in plain words
Quetiapine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Monitor for anticholinergic effects and obtain an ECG in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Quetiapine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine has anticholinergic activity through its metabolite and can add to tiotropium antimuscarinic effects. It can also prolong the QT interval, which olodaterol-related hypokalemia and sympathetic stimulation may worsen.
How serious is the interaction between Quetiapine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and obtain an ECG in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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