Drug interactions
Quetiapine + Trazodone
Severity: Moderate
Quetiapine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, cause orthostatic hypotension and have some QT-prolonging potential. Combined use may increase drowsiness, falls and arrhythmia risk, especially in older patients. Trazodone is often given with low-dose quetiapine, so the combination is common.
What this interaction means in plain words
Quetiapine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive antihistaminic, alpha-1 blocking and CNS depressant effects with additive QT effects.
What to do
Use the lowest effective doses and monitor for sedation and orthostatic hypotension. Check an ECG if other QT-prolonging drugs or cardiac risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Trazodone?
MediHelp rates the interaction as moderate. Quetiapine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, cause orthostatic hypotension and have some QT-prolonging potential. Combined use may increase drowsiness, falls and arrhythmia risk, especially in older patients. Trazodone is often given with low-dose quetiapine, so the combination is common.
How serious is the interaction between Quetiapine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and orthostatic hypotension. Check an ECG if other QT-prolonging drugs or cardiac risk factors are present.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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