Drug interactions
Quinapril + Silodosin
Severity: Moderate
Quinapril and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and together they may cause an exaggerated first-dose or orthostatic hypotensive response. Older patients and those who are volume-depleted are at greater risk.
What this interaction means in plain words
Quinapril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood pressure lowering from alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure, including standing readings, when either drug is started or adjusted. Counsel the patient on slow position changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Quinapril with Silodosin?
MediHelp rates the interaction as moderate. Quinapril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and together they may cause an exaggerated first-dose or orthostatic hypotensive response. Older patients and those who are volume-depleted are at greater risk.
How serious is the interaction between Quinapril and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when either drug is started or adjusted. Counsel the patient on slow position changes.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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