Drug interactions
Quinidine + Repotrectinib
Severity: Major
Quinidine and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and is expected to markedly lower quinidine exposure, reducing efficacy. Quinidine may in turn increase repotrectinib levels through P-glycoprotein inhibition.
What this interaction means in plain words
Quinidine and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinidine belongs to Anti Parasitic; Repotrectinib belongs to Oncology.
Why it happens
Repotrectinib induces CYP3A4 and P-glycoprotein, while quinidine inhibits P-glycoprotein.
What to do
Avoid the combination. If it is unavoidable, monitor quinidine concentrations and ECG and watch for repotrectinib toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Quinidine with Repotrectinib?
MediHelp rates the interaction as major. Quinidine and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib induces CYP3A4 and is expected to markedly lower quinidine exposure, reducing efficacy. Quinidine may in turn increase repotrectinib levels through P-glycoprotein inhibition.
How serious is the interaction between Quinidine and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it is unavoidable, monitor quinidine concentrations and ECG and watch for repotrectinib toxicity.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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