Drug interactions
Quinidine + Ruxolitinib
Severity: Moderate
Quinidine and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine can raise ruxolitinib exposure, mainly through CYP3A4 inhibition, which may increase the risk of cytopenias such as thrombocytopenia and neutropenia. The effect is likely smaller than with strong CYP3A4 inhibitors because quinidine is a weaker CYP3A4 inhibitor.
What this interaction means in plain words
Quinidine and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Ruxolitinib belongs to Oncology.
Why it happens
Quinidine inhibits CYP3A4-mediated metabolism of ruxolitinib, increasing exposure.
What to do
Monitor blood counts more often, and reduce the ruxolitinib dose if cytopenias develop. Follow labeled dose reductions if the interaction is judged to be strong.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Quinidine with Ruxolitinib?
MediHelp rates the interaction as moderate. Quinidine and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine can raise ruxolitinib exposure, mainly through CYP3A4 inhibition, which may increase the risk of cytopenias such as thrombocytopenia and neutropenia. The effect is likely smaller than with strong CYP3A4 inhibitors because quinidine is a weaker CYP3A4 inhibitor.
How serious is the interaction between Quinidine and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts more often, and reduce the ruxolitinib dose if cytopenias develop. Follow labeled dose reductions if the interaction is judged to be strong.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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