Drug interactions
Quinidine + Sevoflurane
Severity: Moderate
Quinidine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval. During anesthesia the combination may raise the risk of torsades de pointes, especially with electrolyte disturbance or bradycardia. Quinidine may also enhance neuromuscular blockade.
What this interaction means in plain words
Quinidine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check the baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Quinidine with Sevoflurane?
MediHelp rates the interaction as moderate. Quinidine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval. During anesthesia the combination may raise the risk of torsades de pointes, especially with electrolyte disturbance or bradycardia. Quinidine may also enhance neuromuscular blockade.
How serious is the interaction between Quinidine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during surgery.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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