Drug interactions
Quinidine + Siltuximab
Severity: Moderate
Quinidine and Siltuximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-6 with siltuximab can reverse the suppression of CYP450 enzymes caused by inflammation. CYP3A4 activity may rise and lower quinidine concentrations, with a risk of reduced efficacy.
What this interaction means in plain words
Quinidine and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Siltuximab belongs to Miscellaneous.
Why it happens
Siltuximab neutralizes IL-6, which restores CYP3A4 expression and increases the metabolism of quinidine.
What to do
Monitor quinidine serum levels and ECG when siltuximab is started or stopped. Adjust the quinidine dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Frequently asked questions
Can I take Quinidine with Siltuximab?
MediHelp rates the interaction as moderate. Quinidine and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blocking IL-6 with siltuximab can reverse the suppression of CYP450 enzymes caused by inflammation. CYP3A4 activity may rise and lower quinidine concentrations, with a risk of reduced efficacy.
How serious is the interaction between Quinidine and Siltuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine serum levels and ECG when siltuximab is started or stopped. Adjust the quinidine dose according to levels and clinical response.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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