Drug interactions
Quinidine + Stiripentol
Severity: Moderate
Quinidine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so it can change quinidine exposure unpredictably, with a likely increase from P-gp inhibition. Altered quinidine levels may cause toxicity (QT prolongation) or loss of effect.
What this interaction means in plain words
Quinidine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 activity and inhibits P-gp efflux of quinidine.
What to do
Monitor ECG and quinidine plasma concentrations when starting or stopping stiripentol, and adjust quinidine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Quinidine with Stiripentol?
MediHelp rates the interaction as moderate. Quinidine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so it can change quinidine exposure unpredictably, with a likely increase from P-gp inhibition. Altered quinidine levels may cause toxicity (QT prolongation) or loss of effect.
How serious is the interaction between Quinidine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and quinidine plasma concentrations when starting or stopping stiripentol, and adjust quinidine dose accordingly.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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