Drug interactions
Quinidine + Tiotropium-olodaterol
Severity: Major
Quinidine and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine prolongs the QT interval and can cause torsades de pointes, and olodaterol may add to this through hypokalemia and sympathetic stimulation. Quinidine also has anticholinergic properties that may add to tiotropium effects.
What this interaction means in plain words
Quinidine and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinidine belongs to Anti Parasitic; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-mediated hypokalemia and additive antimuscarinic effects.
What to do
Monitor ECG and potassium and magnesium during combined therapy. Consider an alternative if the QTc lengthens significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Quinidine and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Quinidine and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine prolongs the QT interval and can cause torsades de pointes, and olodaterol may add to this through hypokalemia and sympathetic stimulation. Quinidine also has anticholinergic properties that may add to tiotropium effects.
How serious is the interaction between Quinidine and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium and magnesium during combined therapy. Consider an alternative if the QTc lengthens significantly.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
