Drug interactions
Quinidine + Vortioxetine
Severity: Moderate
Quinidine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a strong CYP2D6 inhibitor and raises vortioxetine exposure substantially, which increases nausea and other dose-related adverse effects. Labeling recommends halving the vortioxetine dose with strong CYP2D6 inhibitors.
What this interaction means in plain words
Quinidine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Vortioxetine belongs to Central Nervous System.
Why it happens
Quinidine inhibits CYP2D6-mediated metabolism of vortioxetine, increasing its exposure.
What to do
Reduce the vortioxetine dose by about half while quinidine is given. Return to the original dose when quinidine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Quinidine with Vortioxetine?
MediHelp rates the interaction as moderate. Quinidine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a strong CYP2D6 inhibitor and raises vortioxetine exposure substantially, which increases nausea and other dose-related adverse effects. Labeling recommends halving the vortioxetine dose with strong CYP2D6 inhibitors.
How serious is the interaction between Quinidine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vortioxetine dose by about half while quinidine is given. Return to the original dose when quinidine is stopped.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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