Drug interactions
Quinine + Talazoparib
Severity: Moderate
Quinine and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits P-glycoprotein, and talazoparib is a P-gp substrate. Talazoparib exposure may rise, increasing the risk of hematologic toxicity.
What this interaction means in plain words
Quinine and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Talazoparib belongs to Oncology.
Why it happens
Inhibition of P-gp efflux by quinine increases talazoparib absorption and reduces its elimination.
What to do
Monitor blood counts closely for cytopenias. Reduce the talazoparib dose if the product labeling advises it or if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Quinine with Talazoparib?
MediHelp rates the interaction as moderate. Quinine and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits P-glycoprotein, and talazoparib is a P-gp substrate. Talazoparib exposure may rise, increasing the risk of hematologic toxicity.
How serious is the interaction between Quinine and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely for cytopenias. Reduce the talazoparib dose if the product labeling advises it or if toxicity develops.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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