Drug interactions
Quinine + Teclistamab
Severity: Moderate
Quinine and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release after teclistamab may temporarily suppress CYP450 enzymes and raise quinine levels. This can increase quinine toxicity, including QT prolongation.
What this interaction means in plain words
Quinine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity reduces quinine clearance.
What to do
Monitor for quinine toxicity such as cinchonism, hypoglycemia and QT prolongation after teclistamab doses, particularly during CRS. Adjust therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Quinine with Teclistamab?
MediHelp rates the interaction as moderate. Quinine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release after teclistamab may temporarily suppress CYP450 enzymes and raise quinine levels. This can increase quinine toxicity, including QT prolongation.
How serious is the interaction between Quinine and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity such as cinchonism, hypoglycemia and QT prolongation after teclistamab doses, particularly during CRS. Adjust therapy as needed.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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