Drug interactions
Quinupristin / dalfopristin + Silodosin
Severity: Moderate
Quinupristin / dalfopristin and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase silodosin exposure. This could increase orthostatic hypotension and dizziness. Clinical data with silodosin are lacking.
What this interaction means in plain words
Quinupristin / dalfopristin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing silodosin metabolism.
What to do
Monitor blood pressure and orthostatic symptoms during the short antibiotic course, and counsel the patient to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Quinupristin / dalfopristin with Silodosin?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may increase silodosin exposure. This could increase orthostatic hypotension and dizziness. Clinical data with silodosin are lacking.
How serious is the interaction between Quinupristin / dalfopristin and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during the short antibiotic course, and counsel the patient to rise slowly.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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