Drug interactions
Quizartinib + Ranolazine
Severity: Major
Quizartinib and Ranolazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval and is labeled with a boxed warning for torsades de pointes. Adding ranolazine, which also lengthens the QT interval, increases the arrhythmia risk further.
What this interaction means in plain words
Quizartinib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quizartinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QTc prolongation; ranolazine is also a weak CYP3A inhibitor and quizartinib is a CYP3A substrate.
What to do
Avoid the combination where an alternative antianginal is feasible. If used together, monitor ECGs frequently, keep potassium and magnesium normal, and reduce or hold quizartinib according to its labeled QTc thresholds.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Quizartinib with Ranolazine?
MediHelp rates the interaction as major. Quizartinib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval and is labeled with a boxed warning for torsades de pointes. Adding ranolazine, which also lengthens the QT interval, increases the arrhythmia risk further.
How serious is the interaction between Quizartinib and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antianginal is feasible. If used together, monitor ECGs frequently, keep potassium and magnesium normal, and reduce or hold quizartinib according to its labeled QTc thresholds.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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