Drug interactions
Rabeprazole + Vismodegib
Severity: Minor
Rabeprazole and Vismodegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib has pH-dependent solubility, and acid-suppressing drugs may reduce its absorption. Labeling notes that the effect on efficacy is unknown, and a clinical pharmacokinetic study showed no clinically meaningful change.
What this interaction means in plain words
Rabeprazole and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Higher gastric pH may lower vismodegib solubility and absorption.
What to do
No dose change is required. Monitor tumor response during combination therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
Frequently asked questions
Can I take Rabeprazole with Vismodegib?
MediHelp rates the interaction as minor. Rabeprazole and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vismodegib has pH-dependent solubility, and acid-suppressing drugs may reduce its absorption. Labeling notes that the effect on efficacy is unknown, and a clinical pharmacokinetic study showed no clinically meaningful change.
How serious is the interaction between Rabeprazole and Vismodegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor tumor response during combination therapy.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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