Drug interactions
Omeprazole + Vismodegib
Severity: Moderate
Omeprazole and Vismodegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs raising gastric pH may lower vismodegib solubility and absorption. The effect on vismodegib efficacy is unknown, but sustained acid suppression could in theory reduce exposure.
What this interaction means in plain words
Omeprazole and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omeprazole belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Higher gastric pH may reduce vismodegib solubility and thereby bioavailability, although labeling reports no clinically meaningful change.
What to do
Monitor tumor response and consider whether acid suppression is essential during vismodegib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
- Calcium carbonate + Vismodegib Minor
Frequently asked questions
Can I take Omeprazole with Vismodegib?
MediHelp rates the interaction as moderate. Omeprazole and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drugs raising gastric pH may lower vismodegib solubility and absorption. The effect on vismodegib efficacy is unknown, but sustained acid suppression could in theory reduce exposure.
How serious is the interaction between Omeprazole and Vismodegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider whether acid suppression is essential during vismodegib therapy.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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