Drug interactions
Pantoprazole + Vismodegib
Severity: Moderate
Pantoprazole and Vismodegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib has pH-dependent solubility, so raising gastric pH with pantoprazole may reduce its absorption. The impact on antitumor efficacy has not been established.
What this interaction means in plain words
Pantoprazole and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pantoprazole belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Higher gastric pH reduces vismodegib solubility and oral bioavailability.
What to do
Monitor for reduced tumor response. Stop the PPI if clinically possible or choose an alternative acid-reducing approach.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
- Calcium carbonate + Vismodegib Minor
Frequently asked questions
Can I take Pantoprazole with Vismodegib?
MediHelp rates the interaction as moderate. Pantoprazole and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vismodegib has pH-dependent solubility, so raising gastric pH with pantoprazole may reduce its absorption. The impact on antitumor efficacy has not been established.
How serious is the interaction between Pantoprazole and Vismodegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response. Stop the PPI if clinically possible or choose an alternative acid-reducing approach.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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