Drug interactions
Famotidine + Vismodegib
Severity: Moderate
Famotidine and Vismodegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib has pH-dependent solubility, so acid-reducing drugs may lower its absorption. The effect on efficacy is unknown.
What this interaction means in plain words
Famotidine and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Higher gastric pH decreases vismodegib solubility and bioavailability.
What to do
Monitor tumour response, and avoid unnecessary acid suppression where an alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
- Calcium carbonate + Vismodegib Minor
Frequently asked questions
Can I take Famotidine with Vismodegib?
MediHelp rates the interaction as moderate. Famotidine and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vismodegib has pH-dependent solubility, so acid-reducing drugs may lower its absorption. The effect on efficacy is unknown.
How serious is the interaction between Famotidine and Vismodegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumour response, and avoid unnecessary acid suppression where an alternative exists.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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