Drug interactions
Esomeprazole + Vismodegib
Severity: Moderate
Esomeprazole and Vismodegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib solubility is pH dependent, so acid-reducing drugs may alter its absorption. The clinical impact on efficacy has not been established.
What this interaction means in plain words
Esomeprazole and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esomeprazole belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Increased gastric pH may reduce vismodegib solubility and bioavailability.
What to do
Monitor tumor response; consider avoiding long-term PPI therapy if alternatives are available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
- Calcium carbonate + Vismodegib Minor
Frequently asked questions
Can I take Esomeprazole with Vismodegib?
MediHelp rates the interaction as moderate. Esomeprazole and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vismodegib solubility is pH dependent, so acid-reducing drugs may alter its absorption. The clinical impact on efficacy has not been established.
How serious is the interaction between Esomeprazole and Vismodegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response; consider avoiding long-term PPI therapy if alternatives are available.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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