Drug interactions
Dexlansoprazole + Vismodegib
Severity: Moderate
Dexlansoprazole and Vismodegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib has pH-dependent solubility, and acid-suppressing drugs may lower its absorption. The effect on efficacy is not established, but reduced exposure could weaken tumor control.
What this interaction means in plain words
Dexlansoprazole and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Higher gastric pH decreases vismodegib solubility and bioavailability.
What to do
Monitor for treatment response; consider avoiding long-term PPI use if an alternative approach to acid suppression is feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Vismodegib
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
- Calcium carbonate + Vismodegib Minor
Frequently asked questions
Can I take Dexlansoprazole with Vismodegib?
MediHelp rates the interaction as moderate. Dexlansoprazole and Vismodegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vismodegib has pH-dependent solubility, and acid-suppressing drugs may lower its absorption. The effect on efficacy is not established, but reduced exposure could weaken tumor control.
How serious is the interaction between Dexlansoprazole and Vismodegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment response; consider avoiding long-term PPI use if an alternative approach to acid suppression is feasible.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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