Drug interactions
Raltegravir + Sodium zirconium cyclosilicate
Severity: Minor
Raltegravir and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate raises gastric pH, and raltegravir absorption can change with elevated gastric pH, potentially increasing exposure. The effect is generally not considered clinically significant for raltegravir at standard doses.
What this interaction means in plain words
Raltegravir and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Raltegravir belongs to Anti Virals; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH may alter the solubility and absorption of raltegravir.
What to do
Administer raltegravir at least 2 hours before or after sodium zirconium cyclosilicate; no dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicated
- Aluminum hydroxide / magnesium carbonate + Raltegravir Major
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Major
- Aluminum hydroxide + Raltegravir Major
- Atidarsagene autotemcel + Raltegravir Major
- Betibeglogene autotemcel + Raltegravir Major
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Raltegravir with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Raltegravir and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate raises gastric pH, and raltegravir absorption can change with elevated gastric pH, potentially increasing exposure. The effect is generally not considered clinically significant for raltegravir at standard doses.
How serious is the interaction between Raltegravir and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer raltegravir at least 2 hours before or after sodium zirconium cyclosilicate; no dose change is needed.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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