Drug interactions
Ramelteon + Risperidone
Severity: Minor
Ramelteon and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause somnolence and orthostatic dizziness, and ramelteon can add to drowsiness. The combination may impair alertness, especially at the start of treatment or in older adults.
What this interaction means in plain words
Ramelteon and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no meaningful pharmacokinetic interaction is established.
What to do
Counsel on additive drowsiness and fall risk, particularly in older patients. Reduce doses if daytime impairment appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Ramelteon with Risperidone?
MediHelp rates the interaction as minor. Ramelteon and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Risperidone can cause somnolence and orthostatic dizziness, and ramelteon can add to drowsiness. The combination may impair alertness, especially at the start of treatment or in older adults.
How serious is the interaction between Ramelteon and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive drowsiness and fall risk, particularly in older patients. Reduce doses if daytime impairment appears.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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