Drug interactions
Ramelteon + Stiripentol
Severity: Moderate
Ramelteon and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can inhibit and induce CYP1A2, so its effect on ramelteon exposure is unpredictable. Ramelteon levels may increase, causing more sedation, or decrease, reducing efficacy.
What this interaction means in plain words
Ramelteon and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramelteon belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP1A2 activity, altering ramelteon clearance.
What to do
Monitor sleep response and sedation when stiripentol is started or stopped, and adjust the ramelteon dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ramelteon and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Ramelteon with Stiripentol?
MediHelp rates the interaction as moderate. Ramelteon and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can inhibit and induce CYP1A2, so its effect on ramelteon exposure is unpredictable. Ramelteon levels may increase, causing more sedation, or decrease, reducing efficacy.
How serious is the interaction between Ramelteon and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sleep response and sedation when stiripentol is started or stopped, and adjust the ramelteon dose accordingly.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
