Drug interactions
Ramelteon + Trazodone
Severity: Minor
Ramelteon and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote sleep, so combined use may cause excessive drowsiness, dizziness or next-day impairment. Trazodone is also associated with orthostatic hypotension, which may raise fall risk.
What this interaction means in plain words
Ramelteon and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression; trazodone acts via 5-HT2A and H1 antagonism and ramelteon via MT1/MT2 agonism.
What to do
Counsel on additive sedation and fall risk, especially in older adults. Use the lowest effective doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Ramelteon with Trazodone?
MediHelp rates the interaction as minor. Ramelteon and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs promote sleep, so combined use may cause excessive drowsiness, dizziness or next-day impairment. Trazodone is also associated with orthostatic hypotension, which may raise fall risk.
How serious is the interaction between Ramelteon and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and fall risk, especially in older adults. Use the lowest effective doses.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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