Drug interactions
Ramelteon + Trimipramine
Severity: Minor
Ramelteon and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a sedating tricyclic antidepressant with strong antihistaminic activity. Adding ramelteon may increase drowsiness and impair next-day alertness. No important pharmacokinetic interaction is expected.
What this interaction means in plain words
Ramelteon and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Warn about additive sedation and avoid driving until the response is known. Reduce the dose of one agent if daytime drowsiness persists.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Ramelteon with Trimipramine?
MediHelp rates the interaction as minor. Ramelteon and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimipramine is a sedating tricyclic antidepressant with strong antihistaminic activity. Adding ramelteon may increase drowsiness and impair next-day alertness. No important pharmacokinetic interaction is expected.
How serious is the interaction between Ramelteon and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about additive sedation and avoid driving until the response is known. Reduce the dose of one agent if daytime drowsiness persists.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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