Drug interactions
Ramelteon + Zileuton
Severity: Moderate
Ramelteon and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is metabolized mainly by CYP1A2, and zileuton may increase its exposure. This could lead to greater sedation and next-day drowsiness.
What this interaction means in plain words
Ramelteon and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramelteon belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, reducing ramelteon clearance.
What to do
Monitor for excess sedation and dizziness. Consider a lower ramelteon dose or an alternative hypnotic if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Zileuton?
MediHelp rates the interaction as moderate. Ramelteon and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ramelteon is metabolized mainly by CYP1A2, and zileuton may increase its exposure. This could lead to greater sedation and next-day drowsiness.
How serious is the interaction between Ramelteon and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness. Consider a lower ramelteon dose or an alternative hypnotic if adverse effects occur.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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