Drug interactions
Ranolazine + Repaglinide
Severity: Moderate
Ranolazine and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine may increase repaglinide exposure by inhibiting hepatic uptake and possibly CYP-mediated metabolism. Higher repaglinide levels could cause hypoglycemia.
What this interaction means in plain words
Ranolazine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Ranolazine may inhibit OATP1B1 uptake and CYP3A4 metabolism of repaglinide.
What to do
Monitor blood glucose more closely after starting ranolazine and educate the patient about hypoglycemia symptoms. Lower the repaglinide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Ranolazine with Repaglinide?
MediHelp rates the interaction as moderate. Ranolazine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine may increase repaglinide exposure by inhibiting hepatic uptake and possibly CYP-mediated metabolism. Higher repaglinide levels could cause hypoglycemia.
How serious is the interaction between Ranolazine and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely after starting ranolazine and educate the patient about hypoglycemia symptoms. Lower the repaglinide dose if glucose falls.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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