Drug interactions
Ranolazine + Sarecycline
Severity: Minor
Ranolazine and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may inhibit P-glycoprotein, a transporter involved in ranolazine disposition, which could modestly increase ranolazine exposure. The clinical significance is likely small given the low systemic effect of sarecycline.
What this interaction means in plain words
Ranolazine and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible inhibition of P-gp mediated ranolazine efflux by sarecycline.
What to do
No dose adjustment is usually needed. Watch for ranolazine adverse effects such as dizziness, constipation and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Ranolazine with Sarecycline?
MediHelp rates the interaction as minor. Ranolazine and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may inhibit P-glycoprotein, a transporter involved in ranolazine disposition, which could modestly increase ranolazine exposure. The clinical significance is likely small given the low systemic effect of sarecycline.
How serious is the interaction between Ranolazine and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for ranolazine adverse effects such as dizziness, constipation and nausea.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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