Drug interactions
Ranolazine + Sertraline
Severity: Minor
Ranolazine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QTc prolongation, although sertraline's effect is generally small. Combined use may modestly add to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Ranolazine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Possible additive prolongation of cardiac repolarization.
What to do
Check a baseline ECG in patients with other QT risk factors and correct low potassium or magnesium. No routine dose change is needed otherwise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Ranolazine with Sertraline?
MediHelp rates the interaction as minor. Ranolazine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been associated with QTc prolongation, although sertraline's effect is generally small. Combined use may modestly add to arrhythmia risk in susceptible patients.
How serious is the interaction between Ranolazine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG in patients with other QT risk factors and correct low potassium or magnesium. No routine dose change is needed otherwise.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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