Drug interactions
Ranolazine + Simvastatin
Severity: Moderate
Ranolazine and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine increases simvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Labeling limits the simvastatin dose when they are used together.
What this interaction means in plain words
Ranolazine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
Ranolazine weakly inhibits CYP3A4, reducing simvastatin metabolism.
What to do
Limit simvastatin to 20 mg daily with ranolazine. Counsel patients to report muscle pain and check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Ranolazine with Simvastatin?
MediHelp rates the interaction as moderate. Ranolazine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine increases simvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Labeling limits the simvastatin dose when they are used together.
How serious is the interaction between Ranolazine and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit simvastatin to 20 mg daily with ranolazine. Counsel patients to report muscle pain and check CK if symptoms occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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